Figure 6.
Inactivation of SOM, but Not PV, Interneurons Impairs Spatial Selectivity in Aperiodic Spatial Cells with Firing Fields Not Aligned with Any of the Walls
Aperiodic cells have (1) spatial information values higher than the 99th percentile value of shuffled data and (2) grid and border scores below the criterion for grid and border cells.
(A) Representative aperiodic spatial cell from MEC of animal with hM4D-mCitrine in PV interneurons. Data were collected before CNO, 30 min after, and 12 hr after (left to right). (Top to bottom) Rate maps, trajectory maps, and autocorrelation maps.
(B) Cumulative frequency diagrams showing that mean firing rate, spatial information, and spatial correlation did not change after inactivation of PV interneurons.
(C) Representative aperiodic spatial cell from MEC of animal with hM4D-mCitrine in SOM interneurons, plotted as in (A).
(D) Cumulative frequency diagrams showing that inactivation of SOM interneurons reduced spatial information and spatial correlation in aperiodic spatial cells. Mean firing rate was not changed.
The distribution of absolute scores in (B) and (D) is shown in Figure S4.
See also Figures S1, S2, and S4.