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Mechanisms of aminoglycoside hair cell entry. Two prevailing mechanisms are reported to allow aminoglycosides to enter hair cells—the mechano-electric transducer (MET) channel and endocytosis. The MET channel located at the tips of hair cell stereocilia mediates the flow of ions (including aminoglycosides) from the endolymph compartment into hair cells. Endocytosis mediated drug entry occurs via the invagination of the cell membrane.
