Figure 12.

Effect of Corilagin on schistosomiasis fibrosis in animal model examined by HE staining in 200× magnification. After the mice model was established, HE staining was performed. In each figure, the black arrows indicate the area of fibrotic nodules and the green arrows indicate the fibrin which was stained pink in HE staining. Corilagin treatment significantly reduced the granuloma area in vivo. However, the praziquantel treatment had little effect. (A) High-concentration corilagin group; (B) medium-concentration corilagin group; (C) low-concentration corilagin group; (D) praziquantel group; (E) levofloxacin group; (F) model infection group; (G) control group; (H) average area of granuloma. ^*p < 0.01 compared with the model infection group (n = 6, student's t-test); ^**p < 0.05 compared with the control group (n = 6, student's t-test); #p < 0.01 compared with the control group (n = 6, student's t-test); ##p < 0.05 determined by one-way ANOVA and significant differences from the respective values determined by S-N-K method (n = 6). Data are shown with mean with SD.