Figure 1.

Inflammatory infiltrates in FEPSO can be found all over the brain in gray and white matter. Immunohistochemical staining for CD3⁺ and transglutaminase 2 showed that T cells are mainly located in perivascular cuffs with moderate parenchymal infiltrates in all inspected areas, namely the (A) hippocampus, (B) amygdala, (C) basal ganglia, (D) cortex, (E) cerebellum, and (F) white matter. (G) Quantification of parenchymal T cell infiltrates in the abovementioned areas did not reveal differences in T cell densities. Data shown as median with interquartile range, LGI1 antibody-positive animals are indicated in red and untested animals in black; (ns p > 0.05 Kruskal–Wallis test with Dunn’s post hoc correction, hippocampus n = 15, amygdala n = 9, basal ganglia n = 12, cortex n = 15, cerebellum n = 13, normal controls n = 6) Scale bar corresponds to 50 µm.