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. 2017 Oct 18;8:1328. doi: 10.3389/fimmu.2017.01328

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Copyright © 2017 van Beek, Pouw, Brouwer, van Mierlo, Geissler, Ooijevaar-de Heer, de Boer, van Leeuwen, Rispens, Wouters and Kuijpers.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Two healthy donors lack factor H-related (FHR)-2 protein. (A) Lack of FHR-2 protein in two healthy donors as confirmed by immunoprecipitation using anti-FHR-2, visualized on Western blot by anti-FHR-2.1. Schematic representation of FHR-2 indicates mutations found by sequencing (B) Heparin elution pattern of CFHR2^mut/mut donor. Arrow indicates a conductivity of 14.06 mS/cm, representing the physiological salt concentration. (C) Titration of mixed sera in the FHR-1/2 ELISA. Equal amounts of serum were mixed and incubated at 37°C for >2 h to allow for monomer exchange. NHS, normal human serum.