Figure 2.

PTZ kindling-induced cognitive impairment. (A) Schematic of NOR test. Mice were habituated to the NOR arena in the absence of objects for 15 min per day for 2 consecutive days, after which they were exposed in the same arena for 10 min to two identical objects A and A' for training. 24 h later, they underwent a 5 min test in which one of the objects A' was replaced with a novel object B. (B,C) Bar graphs showing the exploration preference for the familiar and novel object (percent of time exploring each object) in vehicle control and PTZ-kindled mice (n = 8). Values are means ± S.E.M. ^**p < 0.01, unpaired two-tailed Student's t-test.