FIGURE 3.

Effects of A-769662 (A-769, 30 μM unless indicated) on CRCs produced by Ang II (first row, A–C), KCl (second row, E–H), PE (third row, I–L), U-46619 (fourth row, M–P) and VP (last row, Q–S) in large (first column) and small (second column) musculocutanous arteries and large (third column) and small (last column) visceral arteries. FA, femoral artery; EA, epigastric artery; RA, renal artery; MA, mesenteric artery; musMA, mouse MA). Data are mean values ± SE; n values are in parentheses. ^∗ is P < 0.05 (Student’s t-test) comparing the identified sigmoidal curve constant for groups A-769662 and vehicle control (DMSO). EC₅₀, agonist concentration producing ½-maximum contraction. Max, calculated sigmoidal curve maximum tension. Data for A-769662 in (D,I) did not fit a sigmoidal curve, so A-769662 and control data at each agonist concentration were statistically compared. n.d., not determined.