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. 2017 Oct 18;8:756. doi: 10.3389/fphar.2017.00756

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Copyright © 2017 Huang, Smith, Chen, Sharma, Miner, Barbee and Ratz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of metformin (MET, 30 μM, first column) and simvastatin (SIM, 30 μM, second column) on CRCs produced by Ang II (first row, A,B), KCl (second row, C,D), PE (third row, E,F), U-46619 (fourth row, G,H) and VP (last row, I,J) in epigastric artery. Data are mean values ± SE; n values are in parentheses. ^∗ is P < 0.05 (Student’s t-test) comparing A-769662 and vehicle control (DMSO) data at each agonist concentration and for (F), comparing the identified sigmoidal curve constant for groups SIM and vehicle control (DMSO). EC₅₀, agonist concentration producing ½-maximum contraction. Max, calculated sigmoidal curve maximum tension.