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. 2017 Oct 18;8:756. doi: 10.3389/fphar.2017.00756

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Copyright © 2017 Huang, Smith, Chen, Sharma, Miner, Barbee and Ratz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of A-769662 (A-769), berberine (BBR), and simvastatin (SIM) on contractions induced by PE in intact mesenteric artery (A) and by Ca²⁺ in β-escin-permeabilized mesenteric artery (B). Data are mean values ± SE; n values are in parentheses. ^∗ is P < 0.025 (Student’s t-test with Bonferroni correction) comparing the EC₅₀ values of A-769 and BBR groups to the vehicle control (DMSO). EC₅₀, agonist concentration producing ½-maximum contraction. ^∗ placed are SIM data points are P < 0.05 (Student’s t-test) comparing each data point from the SIM group to the control group.