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. 2017 Oct 18;8:756. doi: 10.3389/fphar.2017.00756

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Copyright © 2017 Huang, Smith, Chen, Sharma, Miner, Barbee and Ratz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of A-769662 (A-769), simvastatin (SIM) and metformin (MET) on contractile force and changes in intracellular free Ca²⁺ ([Ca²⁺]_i) in fura-2-loaded renal (A–D) and mesenteric (E,F) arteries. Tissues were contracted with phenylephrine (PE) a first time to obtain control force and [Ca²⁺]_i data, then after stimulus washout exposed to either DMSO (vehicle control) or drug and stimulated a second time ∼30 min later with PE. Data are example tracings of force (A) and [Ca²⁺]_i (B), and summary data (mean force values ± SE; force, (C,E), and [Ca²⁺]_i, (D,F); n = 3–5) expressed as the second response normalized to the first response. ^∗ is P < 0.05 (ANOVA and Dunnett’s) compared to DMSO control.