| Category | OFV | Reduction from base model |
|---|---|---|
| Base model | 7906.342 | |
| Total weight | 7653.456 | −252.886 |
| Allometric weight | 7603.049 | −303.293 |
| Covariates on clearance (CL) | OFV | Reduction from allometric weight model |
|---|---|---|
| *𝚯^M | 7603.04 | −0.009 |
| *𝚯^(AGEYRS/3.2) | 7597.461 | −5.588 |
| *(PCA/59)^𝚯 | 7597.377 | −5.672 |
| *(((PCA/59)^𝚯/((PCA/59)^𝚯 + (375)^𝚯)) | 7598.514 | −4.535 |
| *𝚯^(SCR/0.34) | 7599.596 | −3.453 |
| *𝚯^(HGB/11.4) | 7602.004 | −1.045 |
| *𝚯^(HCT/34) | 7601.93 | −1.119 |
| *𝚯^(ALB/2.9) | 7582.477 | −20.572 |
| *(PLT/242)^𝚯 | 7595.395 | −7.654 |
| +(𝚯*(UFH/173)) | 7524.701 | −78.348 |
| *(1 + 𝚯^((UFH‐173)/173)) | 7601.847 | −1.202 |
| *((1 + UFH)/173)^𝚯 | 7549.449 | −53.6 |
| *𝚯^((1 + UFH)/173) | 7601.592 | −1.457 |
| *(BASE/60)^𝚯 | 7499.852 | −103.197 |
| +(𝚯*(BASE/60)) | 7591.612 | −11.437 |
| Covariates on volume of distribution (VD) | OFV | Reduction from allometric weight model |
|---|---|---|
| *𝚯^M | 7602.93 | −0.119 |
| *𝚯^(AGEYRS/3.2) | 7591.537 | −11.512 |
| *(PCA/59)^𝚯 | 7591.258 | −11.791 |
| *(((PCA/59)^𝚯/((PCA/59)^𝚯 + (375)^𝚯)) | 7594.903 | −8.146 |
| *𝚯^(SCR/0.34) | 7601.487 | −1.562 |
| *𝚯^(HGB/11.4) | 7602.401 | −0.648 |
| *𝚯^(HCT/34) | 7601.729 | −1.32 |
| *𝚯^(ALB/2.9) | 7602.428 | −0.621 |
| *𝚯^(PLT/242) | 7596.276 | −6.773 |
| *((1 + UFH)/173)^𝚯 | 7601.691 | −1.358 |
| +(𝚯*(UFH/173)) | 7601.94 | −1.109 |
| *(1 + 𝚯^((UFH‐173)/173)) | 7598.025 | −5.024 |
| *(BASE/60)^𝚯 | 7593.372 | −9.677 |
AGEYRS, age in years; ALB, albumin; BASE, baseline antithrombin; HCT, haematocrit; HGB, haemoglobin; M, Male; OFV, objective function value; PCA, postconceptional age; PLT, platelet; SCR, serum creatinine; UFH, unfractionated heparin