Figure 5.

Predicted decline rate as a function of covariate settings. Study phase effects are not included, i.e., rates reflect conditions seen in the initial RAPID‐RCT phase of the RAPID programme. Point estimates are bootstrap means, and intervals are 95% bootstrap confidence intervals. Dashed vertical lines indicate point estimates (bootstrap means) under reference conditions for placebo (leftmost line) and A₁‐PI 60 mg kg^–1 week^–1 (rightmost line). –/+ covariate indicates the model‐predicted rate of lung density decline in which the covariate has been set to the 10^th/90^th percentile value, respectively, of a reference individual. A₁‐PI, α‐1 proteinase inhibitor; FEV1, forced expiratory volume in 1 s