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Models evaluated and their objective function values. The final model is indicated by a bold italic font
| Model | Attributes | OFV |
|---|---|---|
| E max + linear mixed effects (lme) model | Interstudy/interarm variance + Additive error | 1223.387 |
| E max + nonlinear mixed effects (nlme) model | Interstudy variance + Additive error | 1113.138 |
| E max + nlme model (BASE MODEL) | Additive error | 1114.638 |
| Exponential + nlme model | Additive error | 1167.391 |
| Covariate model | BASE MODEL + Dose + Contact time | 1103.740 |
