Fig. 1.

Study design for the COMCID trial (ClinicalTrials.govNCT02491268, UMIN Clinical Trials Registry UMIN000017764). (A) Schematic flow diagram of the enrollment process. (B) The schedule of interventions and assessments. MMSE, Mini-Mental State Examination; CDR, Clinical Dementia Rating; ADAS-Cog, Alzheimer's Disease Assessment Scale–cognitive subscale; WMS-R, Wechsler Memory Scale-Revised; TMT, Trail making test; FCSRT, Free and Cued Selective Reminding Test; ADCS-MCI-ADL, Alzheimer's Disease Cooperative Study–Mild Cognitive Impairment–Activities of Daily Living; MRI, magnetic resonance imaging; AEs, adverse events.