Figure 1.

Deletion of Fmr1 resulted in sex‐specific hyperactivity in the open field task. (a) Fmr1 KOs showed significant hyperactivity when examining distance moved in the open field task. Upon further statistical analysis, hyperactivity was only detected in the male knockouts. (b) When exploratory behavior was analyzed in 10‐min epochs, Fmr1 knockouts show similar degrees of habituation during the testing window, however, are more active overall. (c) Fmr1 KOs show increased activity levels specifically in the periphery of the testing apparatus. (d) Male Fmr1 KOs exhibited significantly higher amounts of rearing behavior compared to wild‐types, whereas this effect was not present in females. Data are presented as mean ± SEM. ** = p < .01, *** = p < .001