Fig. 2.

(A) Representative WT (left) and 5XFAD (right) dynamic SPECT/CT brain images in sagittal, axial, and coronal planes. SPECT activity source maps indicate initial uptake and blood–brain barrier penetrance of radiotracer by 3.5 minute post-injection (PI) in both WT and 5XFAD brains, with greater radiotracer retention in the 5XFAD brain compared to WT. Image intensities expressed as percent injected dose per mL (%ID/mL) are set to a common color scale of 0%ID/mL–32%ID/mL. (B) Corresponding whole-brain radiotracer SPECT time-activity curves for 5XFAD (blue) and WT (green) mice (mean ± SEM). Significantly greater cerebral retention is evident in 5XFAD compared to WT. *Denotes statistically significant differences (P < .05); †Indicates a statistical trend (P < .10). Abbreviations: CT, computed tomography; SEM, standard error of the mean; WT, wild-type; 5XFAD, B6SJL-Tg(APPSwFlLon, PSEN1∗M146 L∗L286 V) 6799Vas/Mmjax mouse strain; SPECT, single photon emission computed tomography.