Fig. 4.

Comparison of BChE activity at midcoronal level (as in Fig. 3) in specific brain regions of WT (left) and 5XFAD (right) mice detected with radiotracer SPECT analysis. (A) CT with coregistered MR. (B) SPECT images acquired at 4-minute post-injection with coregistered CT/MR and ROIs. Marked retention in the 5XFAD cerebral cortex is evident in the 5XFAD brain compared to WT with less difference in retention evident in amygdala, hippocampus, basal ganglia, and thalamus. Image intensities expressed as %ID/mL and set to a common scale of 0%ID/mL–40%ID/mL. Abbreviations: A, amygdala; BChE, butyrylcholinesterase; BG, basal ganglia; CC, cerebral cortex; CT, computed tomography; H, hippocampal formation; MR, magnetic resonance; ROIs, regions of interest; SPECT, single photon emission computed tomography; Th, thalamus; WT, wild-type; 5XFAD, B6SJL-Tg(APPSwFlLon, PSEN1∗M146 L∗L286 V) 6799Vas/Mmjax mouse strain.