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. 2017 Jun 24;3(3):416–431. doi: 10.1016/j.trci.2017.06.002

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Results of meta-analyses for circulatory nutrient levels in AD patients and cognitively intact elderly controls. (A) DHA levels are significantly lower in AD patients (P < .05) and approximately 75% of the absolute amount in the control subjects; (B) EPA levels are significantly lower in AD patients (P < .05) and approximately 89% of the absolute amount in the control subjects; (C) choline (as PC) levels are significantly lower in AD patients (P < .05) and approximately 88% of the absolute amount in the control subjects; (D) vitamin B₆ levels are not significantly different in AD patients (P = .3634); (E) Selenium levels are significantly lower in AD patients (P < .05) and approximately 93% of the absolute amount in the control subjects. Abbreviations: AD, Alzheimer's disease; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; LCL, lower confidence limit; PC, plasma phosphatidylcholine; REML, restricted maximum likelihood; SD, standard deviation; UCL, upper confidence limit.