Fig. 2.

Effect of Zfra peptide on Aβ deposition in 3×Tg mice. Representative micrographs of Aβ-positive cells are shown on the left panels, the boxed regions are enlarged and shown on the middle, and the quantitative results are shown on the right. (A) Dorsal hippocampus. (B) Ventral hippocampus. *P < .05 versus respective PBS group, two-tailed unpaired t-test (PBS group, n = 3; Zfra group, n = 5). Also, representative micrographs of cortical Aβ plaques (white arrows) are shown for the PBS controls and Zfra-treated mice on the left panel (C), and the data quantified on the right. Statistics: Zfra versus respective PBS group, two-tailed unpaired t-test (PBS group, n = 3; Zfra group, n = 5). Abbreviations: Aβ, amyloid β; Zfra, zinc finger-like protein that regulates apoptosis.