Table 2.
The associations between long-term anticholinergic use and risk of mild cognitive impairment or Alzheimer's disease using Cox proportional hazards model (N = 723)
| Group | Model 1 |
Model 2 |
Model 3 |
|||
|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Nonusers | 1.00 | 1.00 | 1.00 | |||
| Possible AC users | 1.65 (1.05–2.61) | .031 | 1.67 (1.06–2.66) | .029 | 1.63 (1.02–2.60) | .04 |
| Definite AC users | 0.91 (0.54–1.54) | .731 | 0.91 (0.54–1.53) | .711 | 0.90 (0.53–1.52) | .692 |
Abbreviations: CI, confidence interval; HR, hazard ratio.
NOTE. Model 1: adjusted for sex, race, birth year, years of education, and follow-up time. Model 2: model 1+ smoking status (current, former, never), drinker (never, ever). Model 3: model 2+ number of cardiovascular comorbidities.