Supplementary Fig. 3.

Whole brain-based spatial statistics (WBSS) and tractwise fractional anisotropy statistics (TFAS) of FA maps at the group level for ALS patients, LMND patients (subdivided into slow and fast progressors), and controls. (A) WBSS of FA maps demonstrated multiple clusters of regional FA reductions at p < 0.05 (corrected for multiple comparisons), sagittal projectional views. (B) TFAS demonstrated significant regional FA reductions in ALS-related tract systems and in the grand average predominantly between ALS patients and fast LMND progressors and slow LMND progressors and controls. No alterations between groups were observed in the reference tract. * p < 0.05, ** p < 0.001.