Table 3.
Univariable and multivariable Cox’s proportional hazard models for the association with appropriate ICD therapy
| Univariate analysis | Multivariate analysis model 1 | Multivariate analysis model 2 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Characteristics | HR | 95% CI | P Value | HR | 95% CI | P Value | HR | 95% CI | P Value |
| Age,yrs | 1.01 | 0.96–1.06 | 0.63 | 1.02 | 0.97–1.08 | 0.41 | 1.02 | 0.97–1.08 | 0.43 |
| Male | 3.22 | 0.72–14.42 | 0.13 | ||||||
| Biventricular ICD | 0.49 | 0.15–1.58 | 0.23 | ||||||
| Ischemic cardiomyopathy | 2.42 | 0.83–7.10 | 0.11 | ||||||
| Hypertension | 2.16 | 0.49–9.59 | 0.31 | ||||||
| Diabetes mellitus | 2.04 | 0.72–5.78 | 0.18 | ||||||
| Dyslipidemia | 0.77 | 0.27–2.24 | 0.63 | ||||||
| Serum creatinine, per 0.1 increase | 1.19 | 0.97–1.46 | 0.10 | ||||||
| QRS duration | 1.00 | 0.99–1.02 | 0.72 | ||||||
| NYHA ≥ III | 2.65 | 0.75–9.42 | 0.13 | ||||||
| CMR parameters | |||||||||
| Sphericity index, per 0.01 increase | 1.09 | 1.02–1.16 | 0.007 | 1.09 | 1.02–1.16 | 0.007 | |||
| Sphericity index > 0.57 | 4.49 | 1.53–13.21 | 0.006 | 4.49 | 1.53–13.21 | 0.006 | |||
| RWT, per 0.01 increase | 1.01 | 0.94–1.10 | 0.75 | ||||||
| LV EDVI | 1.01 | 1.00–1.02 | 0.18 | ||||||
| LV ESV | 1.01 | 1.00–1.01 | 0.039 | ||||||
| LV EF, per 1% decrement | 1.09 | 1.03–1.15 | 0.005 | 1.07 | 0.99–1.13 | 0.08 | 1.07 | 0.99–1.13 | 0.08 |
| LV mass index | 1.01 | 1.00–1.02 | 0.039 | ||||||
| LV mass/LV EDV | 4.56 | 0.11–198.25 | 0.43 | ||||||
| LV LGE | 2.45 | 0.78–7.72 | 0.13 | ||||||
| LV LGE2SD | 1.01 | 1.00–1.03 | 0.14 | ||||||
| LV heterogeneous LGE(2-4SD) | 1.07 | 1.02–1.12 | 0.01 | ||||||
| RV EDVI | 1.01 | 0.98–1.03 | 0.58 | ||||||
| RV ESV | 1.01 | 1.00–1.02 | 0.10 | ||||||
| RV EF, per 1% decrement | 1.04 | 1.00–1.08 | 0.054 | ||||||
| RV EF < 40% | 3.92 | 1.42–10.85 | 0.009 | ||||||
Variables given are mean ± SD or N (%) or median (interquartile range)
Abbreviation as in Tables 1 and 2
Model 1 included sphericity index, LVEF and age. Model 2 included sphericity index > 0.57, LVEF and age
HR (hazard ratio) refers to the ratio of hazards of the presence of the characteristic to the reference (absence), or to the change of 1 unit (continuous variable)