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. 2017 Oct 20;18:193. doi: 10.1186/s13059-017-1308-x

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Recombination rate valleys are correlated with hotspot density and DNA methylation. a The relationship between log10(recombination rate) and recombination hotspot density (per kb) at each eQTL interval. Heat colors represent the point density. Recombination hotspot density less than 0.005/kb (red rectangle) was extracted for the analysis in b. b The relationship between average recombination rate and DNA methylation quantiles in GV oocyte stage within eQTL intervals. Error bars indicate the standard deviation