Table 3.

Immunoscore and Immunoprofiling differences

	Immunoscore	Immunoprofiling
	Prognostic/predictive (?)	Prognostic/predictive (?)
Number of Immunomarkers	2–4	1-several
Immunoscore markers	CD3/CD8	Immune gene signatures
Immunoscore-like markers	CD3/CD8/CD20/FoxP3	Multiplex assays
	CD3/CD8/CD45RO	CD137, Galectin1, LAG-3, OX40 PD-L1, TIM3 ect.
	CD3/CD8/CD68
	CD3/CD8/CD20
	CD3/GZMB
	CD8/FoxP3
	CD8/IL17
	(others)
Possible applications	• Staging in colorectal cancer (already tested)	• Prognostic assay
	• Staging in melanoma, breast cancer, Ovarian cancer,  NSCLC, prostate cancer, pancreatic cancer, head and neck cancer (to be defined)	• Diagnostic assay
		• Personalized immune-treatment