Table 4.
Clinical trials of CAR-T cells for solid tumors in China
| Target antigens | Diseases | CAR | Vector | NCT no. |
|---|---|---|---|---|
| GPC3 | Hepatocellular carcinoma | NA | NA | NCT02723942 |
| GPC3 | Hepatocellular carcinoma | CD3ζ, CD28, and 4-1BB | NA | NCT02395250 |
| GPC3 | Lung squamous cell carcinoma | NA | LV | NCT02876978 |
| GPC3 | Hepatocellular carcinoma and liver metastases | 4-1BB | NA | NCT02715362 |
| GPC3 | Hepatocellular carcinoma | 4-1BB | NA | NCT03130712 |
| GPC3 | Advanced hepatocellular carcinoma | 4-1BB-CD3ζ | RV | NCT03084380 |
| GPC3 | Hepatocellular carcinoma, squamous cell lung cancer | NA | NA | NCT03198546 |
| GPC3 | Hepatocellular carcinoma | NA | LV | NCT03146234 |
| GPC3, mesothelin, CEA | Hepatocellular, pancreatic cancer, colorectal cancer | NA | LV | NCT02959151 |
| Mesothelin | Malignant mesothelioma, pancreatic Cancer, ovarian tumor, triple-negative breast cancer, endometrial cancer, other mesothelin-positive tumors | 4-1BB-CD3ζ | RV | NCT02580747 |
| Mesothelin | Recurrent or metastatic malignant tumors | NA | NA | NCT02930993 |
| Mesothelin | Pancreatic cancer and pancreatic ductal a denocarcinoma | 4-1BB | NA | NCT02706782 |
| Mesothelin | Solid tumor, adult advanced cancer | NA | NA | NCT03030001 |
| Mesothelin | Advanced solid tumor | NA | NA | NCT03182803 |
| EpCAM | Liver neoplasms | NA | NA | NCT02729493 |
| EpCAM | Stomach neoplasms | NA | NA | NCT02725125 |
| EpCAM | Nasopharyngeal carcinoma and breast cancer | NA | LV | NCT02915445 |
| EpCAM | Colon cancer, esophageal carcinoma, pancreatic cancer, prostate cancer, gastric cancer, hepatic carcinoma | CD3ζ, CD28 | LV | NCT03013712 |
| GD2 | Neuroblastoma | NA | LV | NCT02765243 |
| GD2 | Relapsed or refractory neuroblastoma | NA | NA | NCT02919046 |
| GD2 | Solid tumor | NA | LV | NCT02992210 |
| HER-2 | Advanced HER-2-positive solid tumors | CD3ζ, 4-1BB-CD3ζ | NA | NCT01935843 |
| HER-2 | Breast cancer | CD28-CD3ζ | RV | NCT02547961 |
| HER-2 | Breast cancer, ovarian cancer, lung cancer, gastric cancer, glioma, pancreatic cancer | NA | NA | NCT02713984 |
| EGFR | Advanced EGFR-positive solid tumors | 4-1BB-CD3ζ | LV | NCT01869166 |
| EGFR | Advanced solid tumor | NA | NA | NCT03182816 |
| EGFR | Colorectal cancer | 4-1BB-CD28-CD3 | NA | NCT03152435 |
| EGFRvIII | Recurrent glioblastoma multiform | NA | LV | NCT02844062 |
| EGFRvIII | Glioblastoma multiform | NA | NA | NCT03170141 |
| MUC1 | Malignant glioma of brain, colorectal carcinoma, gastric carcinoma | NA | NA | NCT02617134 |
| MUC1 | Advanced refractory solid tumor (hepatocellular carcinoma, NSCLC, pancreatic carcinoma, triple-negative invasive breast carcinoma) | CD28-4-1BB- CD3ζ | LV | NCT02587689 |
| MUC1 | Advanced solid tumor | NA | NA | NCT03179007 |
| CEA | Lung cancer, colorectal cancer, gastric cancer, breast cancer, pancreatic cancer | NA | NA | NCT02349724 |
| EphA2 | EphA2-positive malignant glioma | NA | NA | NCT02575261 |
| LMP1 | Nasopharyngeal neoplasms | NA | NA | NCT02980315 |
| MG7 | Liver metastases | 4-1BB | NA | NCT02862704 |
| CD133 | Liver cancer, pancreatic cancer, brain tumor, breast cancer, ovarian tumor, colorectal cancer, ALL, AML | CD3ζ, 4-1BB-CD3ζ | RV | NCT02541370 |
| HerinCAR-PD1 | Advanced malignancies | NA | NA | NCT02873390 |
| HerinCAR-PD1 | Advanced solid tumor (lung, liver, and stomach) | NA | NA | NCT02862028 |
| PD-L1 CSR | Glioblastoma multiform | NA | NA | NCT02937844 |
| NY-ESO-1 | Advanced NSCLC | NA | LV | NCT03029273 |
| Zeushield | NSCLC | NA | NA | NCT03060343 |
| PSCA/MUC1/PD-L1/CD80/86 | Advanced lung or other cancers | NA | NA | NCT03198052 |
| PSMA, FRa | Bladder cancer, urothelial carcinoma bladder | NA | NA | NCT03185468 |
| Claudin18.2 | Advanced gastric adenocarcinoma, pancreatic adenocarcinoma | NA | LV | NCT03159819 |
CTX cyclophosphamide, FLU fludarabine, LV lentiviral, NA not available, NSCLC non-small cell lung cancer, RV retroviral