Skip to main content
. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Exp Hematol. 2017 Jul 10;54:26–30. doi: 10.1016/j.exphem.2017.07.002

Figure 1. Single-cell reduced representation bisulfite sequencing (scRRBS).

Figure 1

New single-cell and clonality methods can be controlled and combined into one channel or tube. (a) The 10 steps of RRBS can be centralized into one plate of reactions and automated for improved reproducibility. These data or inference from deeply sequenced tumor samples can show evolution (left to right), selection after chemotherapy (red), and emergence of chemo-resistant clones that are driven by epigenetic changes called epialleles and shifted epialleles per million loci (EPM).