TABLE 1.
Experimental design and distribution of mice based on their human immune system reconstitution status and human tissue donor origin
| Donor | Group description | Day of euthanasia | Inoculum | Avg reconstitution (%) (range)a |
|---|---|---|---|---|
| 1 | Reconstituted | 3 | Virus | 30.2 (10.1–56.6) |
| 1 | Nonreconstituted | 3 | Virus | NA |
| 1 | Nonreconstituted | 3 | Mock | NA |
| 2 | Reconstituted | 3 | Virus | 36.0 (16.1–68.7) |
| 2 | Reconstituted | 3 | Mock | 44.3 (10.5–78.1) |
| 2 | Nonreconstituted | 3 | Virus | NA |
| 2 | Nonreconstituted | 3 | Mock | NA |
| 1 | Reconstituted | 5 | Virus | 23.6 (11.2–40.7) |
| 1 | Reconstituted | 5 | Mock | 24.4 (10.4–50.2) |
| 1 | Nonreconstituted | 5 | Virus | NA |
| 1 | Nonreconstituted | 5 | Mock | NA |
| 2 | Reconstituted | 5 | Virus | 35.6 (23.0–50.3) |
| 2 | Reconstituted | 5 | Mock | 32.6 (17.6–52.3) |
| 2 | Nonreconstituted | 5 | Virus | NA |
| 2 | Nonreconstituted | 5 | Mock | NA |
Percentage of human versus mouse CD45+ cells, with sorting from 100 μl mouse peripheral blood. NA, nonapplicable.