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Ad5-crMYOC specifically targets human MYOC. The GeneArt genomic cleavage assay shows a cleavage band (from MYOC qPCR product; arrow) in Ad5-crMYOC–treated DNA in all NTM5 cell lines, but not in mouse kidney cell line IMCD3, confirming the gRNA specificity for the human MYOC gene. Cas9 expression appears similar in both Ad5-crMYOC–treated NTM5 and IMCD3 cells.
