Table 3.
The regression of cancer incidence on stem cell division and somatic mutation burden.
| Model | Explanatory variablea | Adjusted-R2 | p-value (SCD) | p-value (DM) | p-value (TSM) |
|---|---|---|---|---|---|
| Model-1 | SCD, DM | 0.374 | 0.030 | 0.042 | NA |
| Model-2 | SCD, TSM | 0.340 | 0.011 | NA | 0.079 |
| Model-3 | SCD | 0.268 | 0.006 | NA | NA |
| Model-4 | DM | 0.247 | NA | 0.008 | NA |
| Model-5 | TSM | 0.139 | NA | NA | 0.041 |
aSCD: the lifetime number of stem cell divisions. DM: the number of somatic mutations in the pan-cancer driver (pcDriver) genes. TSM: the number of somatic mutations present in all HOGO genes. Before the regression analysis, the logarithm transformation is applied to SCD and TSM.