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. 2017 Oct 20;3:31. doi: 10.1038/s41531-017-0033-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Neuropathological changes in the SN of Nrf2 (+/+) or Nrf2 (−/−) mice after treatment with PQ, MPTP or saline (n = 3). a Each microgram (100×) shows a representative perspective view of SN immunostained with TH from each group. b The loss of TH-positive DA neurons induced by PQ or MPTP in each group, reflected by numbers of residual neurons. ▲ Nrf2 (+/+) PQ10 vs. Nrf2 (+/+) saline (p < 0.01), ★ Nrf2 (+/+) MPTP30 vs. Nrf2 (+/+) saline (p < 0.01), ● Nrf2 (−/−) PQ10 vs. Nrf2 (−/−) saline (p < 0.01), ■ Nrf2 (−/−) MPTP30 vs. Nrf2 (−/−) saline (p < 0.01), ▽ Nrf2 (−/−) PQ10 vs. Nrf2 (+/+) PQ10 (p < 0.05), ◎ Nrf2 (−/−) MPTP30 vs. Nrf2 (+/+) MPTP30 (p < 0.05)