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. 2017 Oct 20;3:31. doi: 10.1038/s41531-017-0033-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — The expression level of miR-380-3p in the SN of Nrf2 (+/+) and Nrf2 (−/−)after treatment with PQ, MPTP or saline. The arrows indicated the signal of LNA™ probes for miR-380-3p. a The expression intensity of miR-380-3p analyzed by LNA–ISH hybridization in the SN of Nrf2 (+/+) ICR mice after saline, PQ or MPTP treatment (n = 3); each microgram (400×) shows a representative view of a slice of the SN from each group. b The expression intensity of miR-380-3p analyzed by LNA–ISH hybridization in Nrf2 (−/−) ICR mice SN after saline, PQ or MPTP treatment (n = 3); each microgram (400×) shows a representative view of a slice of the SN from each group. c The expression levels of miR-380-3p analyzed by real-time PCR in Nrf2 (+/+) and Nrf2 (−/−) SN after treatment with PQ, MPTP or saline (n = 4). ◆ Nrf2 (+/+) PQ5 vs. Ap (p < 0.01), ▲ Nrf2 (+/+) PQ10 vs. Nrf2 (+/+) saline (p < 0.01), ★ Nrf2 (+/+) MPTP30 vs. Nrf2 (+/+) saline (p < 0.01), □Nrf2 (−/−) PQ5 vs. Nrf2 (−/−) saline (p < 0.01), ●Nrf2 (−/−) PQ10 vs. Nrf2 (−/−) saline (p < 0.01), ■ Nrf2 (−/−) MPTP30 vs. Nrf2 (−/−) saline (p < 0.01), ◎ Nrf2 (−/−) MPTP30 vs. Nrf2 (+/+) MPTP30 (p < 0.01)