Table 3.
Alteration of the expression profile of microRNAs in SN tissues of Nrf2 (+/+) ICR or Nrf2 (−/−) ICR mice after treatment with PQ or MPTP
| Analysis | Mice group | Change miRNAs(≥1.5 fold, p < 0.05) | Fig. |
|---|---|---|---|
| The essential relevance between miRNA and transcription factor Nrf2. | Nrf2 (+/+) Saline—Nrf2(–/–) Saline | miR-128, miR-7a, miR-669c, miR-298, miR-543, miR-770-5p, miR-669b* and miR-544-5p | S1 |
| Changes in miRNA expression profile after exposure to paraquat. | [Nrf2 (+/+) PQ5—Nrf2 (+/+) Saline] + [Nrf2 (+/+) PQ10—Nrf2 (+/+) Saline] | miR-140, miR-380-3p | S2a and 2b |
| Changes in miRNA expression profile after exposure to MPTP. | Nrf2 (+/+) MPTP30—Nrf2 (+/+) Saline | miR-140, miR-380-3p | S2c |
| The relationship between transcription factor Nrf2 and changes in miRNA expression profile after exposure to paraquat or MPTP. | |||
| 1.Nrf2-independent effect of 5/10 mg / kg PQ,MPTP | [Nrf2(–/–) PQ5—Nrf2(–/–) Saline] + [Nrf2(–/–) PQ10 − Nrf2(–/–) Saline] + [Nrf2 (–/–) MPTP30 − Nrf2(–/–) Saline] | miR-135b(either PQ or MPTP) | S3a, 3b and 3c |
| [Nrf2(–/–) PQ5—Nrf2(–/–) Saline] + [Nrf2(–/–) PQ10 − Nrf2(–/–) Saline] | miR-142-5p and miR-451 (PQ treatment at 5/10 mg / kg) | ||
| 2.Nrf2-independent effect of MPTP | [Nrf2 (+/+) MPTP30—Nrf2(+/+) Saline] + [Nrf2 (–/–) MPTP30 − Nrf2(–/–) Saline] | miR-674*, miR-133b, miR-135b and miR-380-3p | S4a and 4b |
| 3.Nrf2-independent effect of 5 mg / kg PQ | [Nrf2(+/+) PQ5—Nrf2(+/+) Saline] + [Nrf2(–/–) PQ5 − Nrf2(–/–) Saline] | miR-140 | S5a and 5b |
| 4.Nrf2-independent effect of 10 mg / kg PQ | [Nrf2(+/+) PQ10—Nrf2(+/+) Saline] + [Nrf2(–/–) PQ10 − Nrf2(–/–) Saline] | null | S6a and 6b |
| 5.Nrf2-dependent effect of 5/10 mg / kg PQ | [Nrf2 (+/+) Saline—Nrf2(+/+) Saline] + [Nrf2(+/+) PQ5—Nrf2(+/+) Saline] + [Nrf2(+/+) PQ10 − Nrf2(+/+) Saline] | miR-376c, miR-154* and miR-377 | S10a and 10b |
| 6.Nrf2-dependent effect of MPTP | Nrf2 (+/+) MPTP30—Nrf2(–/–) MPTP30 | miR-410, miR-379, miR-669c*, miR-467g, miR-669f-3p, miR-1902, miR-615-3p, miR-99b*, miR-138-1, miR-378/miR-378b, miR-351, miR-let-7d*, miR-34b-3p, miR-543, miR-376c* and miR-380-3p. | S7 |
| 7.Nrf2-dependent effect of 5 mg / kg PQ | Nrf2(+/+) PQ5—Nrf2(–/–) PQ5 | miR-135a, miR-376c, miR-31, miR-let-7i*, miR-669b*, miR-344, miR-15b, miR-700*, miR-3099, miR-377, miR-338-5p, miR-382, miR-219-3p and miR-310a | S8 |
| 8.Nrf2-dependent effect of 10 mg / kg PQ | Nrf2(+/+) PQ10—Nrf2(–/–) PQ10 | miR-495*, miR-154*, miR-let-7b, miR-1983, miR-103 and miR-26a | S9 |