Table 4.
Impact of the subject misclassification secondary to analytical and biological variation alone on the potential increase in the prevalence of various diagnostic categories.
| Potential increase in prevalence caused by misclassified subjects | ||||||
|---|---|---|---|---|---|---|
| Original classification | WHO criteria | ADA criteria | ||||
| Normal (%) | Impaired (%) | Diabetes (%) | Normal (%) | Impaired (%) | Diabetes (%) | |
| Normal fasting plasma glucose | — | 46.8 | 0 | — | 32.5 | 0 |
| Impaired fasting plasma glucose | 1.9 | — | 14.4 | 6.6 | — | 14.2 |
| Diabetes | 0.01 | 7 | — | 0 | 2.2 | — |
| Normal oral glucose tolerance test | — | 36.8 | 0 | — | 36.8 | 0 |
| Impaired oral glucose tolerance test | 6.2 | — | 26.6 | 6.2 | — | 26.6 |
| Diabetes | 0.01 | 6.8 | — | 0.01 | 6.8 | — |
| Normal HbA1c (at CVa = 3.5%) | — | 48 | 1.3 | — | 16.5 | 0 |
| Pre-diabetes | 6.4 | — | 31.8 | 25.3 | — | 33.1 |
| Diabetes | 0.03 | 4.4 | — | 0 | 1.6 | — |
| Normal HbA1c (at CVa = 2.0%) | — | 30.5 | 0 | — | 11.6 | 0 |
| Pre-diabetes | 5.2 | — | 17.9 | 19.5 | — | 18.2 |
| Diabetes | 0 | 3.6 | — | 0 | 1.2 | — |
This is calculated by using the dividing the number of misclassified subjects with the original number of subjects within each diagnostic category.