Table 1.

Inhibitory activities of 1 and 2 on cPLA₂ at 10 μM and their physiochemical properties.

Cpd	R2	m	n	R1	% cPLA2 Activity	% Inhibition	PSAa	Cpd	R3	q	R1	% cPLA2 Activity	% Inhibition	PSAa
1a	CF3	2	4	C5H11	40.0 ± 0.9	60.0	17.1	2a		2	C5H11	39.7 ± 2.6	60.3	66.4
1b	CF3	2	4	C3H7	37.0 ± 3.9	63.0	17.1	2b		2	C5H11	26.7 ± 0.1	73.3	66.4
1c	CF3	2	4	C8H17	45.0 ± 3.5	55.0	17.1	2c		2	C5H11	40.9 ± 1.1	59.1	66.4
1d	CF3	2	4	Ph	31.8 ± 2.0	68.2	17.1	2d		2	C5H11	13.2 ± 1.2	86.8	66.4
1e	CF3	1	4	C6H13	40.5 ± 3.6	59.5	17.1	2e		2	C5H11	25.8 ± 0.1	74.2	66.4
1f	CF3	2	3	C5H11	33.8 ± 2.2	66.2	17.1	2f		2	C5H11	35.6 ± 2.1	64.4	66.4
1g	CF3	2	3	C3H7	42.5 ± 0.3	57.5	17.1	2g		3	C5H11	15.5 ± 0.3	84.5	66.4
1h	CF3	2	3	C8H17	45.6 ± 2.8	54.4	17.1	2h		3	C3H7	43.6 ± 0.2	56.4	66.4
1i	CF3	2	2	C5H11	36.4 ± 3.3	63.6	17.1	2i		3	C5H11	11.5 ± 1.0	88.5	66.4
1j	CF3	2	2	C7H15	33.9 ± 4.8	66.1	17.1	2j		3	C3H7	16.5 ± 1.2	83.5	66.4
1k	CF3	2	2	C11H23	54.0 ± 6.9	46.0	17.1	2k		4	C5H11	37.7 ± 1.5	62.3	66.4
1l	CF3	2	2	C13H27	72.4 ± 12.9	27.6	17.1	2l		2	C5H11	67.4 ± 5.7	32.6	72.2
1m	NH2	2	4	C5H11	60.7 ± 1.9	39.3	43.1	2m		2	C5H11	57.5 ± 1.4	42.5	72.2
1n	CClF2	2	4	C5H11	49.2 ± 4.5	50.8	17.1	2n		2	C5H11	33.3 ± 0.9	66.7	66.4
1o	CHF2	2	4	C5H11	40.2 ± 0.5	59.8	17.1	2o		2	C5H11	65.5 ± 4.0	34.5	66.4
								2p		2	C5H11	53.9 ± 2.7	46.1	89.3
								2q		1	C5H11	56.6 ± 4.9	43.4	66.4
								20c		2	C5H11	84.8 ± 1.0	15.2	55.4

^aValues were obtained from ChemBioDraw Ultra 12.