Table 3.
Annotation for differentially expressed circRNAs/miRNAs interaction.
| CircRNA ID | P-value | FDR | FC | Regulation | MRE1 | MRE2 | MRE3 | MRE4 | MRE5 |
|---|---|---|---|---|---|---|---|---|---|
| hsa_circ_0003528 | 0.037466755 | 0.115427239 | 5.341549 | up | miR-421 | miR-181a-2-3p | miR-505-3p | miR-429 | miR-380-5p |
| hsa_circ_0001417 | 0.013874737 | 0.062154272 | 5.3239089 | up | miR-298 | miR-766-5p | miR-323a-5p | miR-138-5p | miR-486-3p |
| hsa_circ_0043497 | 0.049072061 | 0.137777454 | 4.866483 | up | miR-335-3p | miR-186-5p | miR-380-5p | miR-296-3p | miR-522-3p |
| hsa_circ_0038929 | 0.008851434 | 0.04811339 | 4.7593614 | up | miR-485-5p | miR-221-5p | miR-492 | miR-182-5p | miR-545-3p |
| hsa_circ_0000994 | 0.02769979 | 0.094239935 | 4.2102057 | up | miR-27b-3p | miR-27a-3p | miR-373-5p | miR-335-3p | miR-628-5p |
| hsa_circ_0001216 | 0.019989045 | 0.076864421 | 4.0183976 | up | miR-326 | miR-3154 | miR-4747-5p | miR-676-5p | miR-330-5p |
| hsa_circ_0007705 | 0.000698384 | 0.012309287 | 3.6367029 | up | miR-103a-2-5p | miR-190a-5p | miR-578 | miR-22-5p | miR-190b |
| hsa_circ_0030045 | 0.010558813 | 0.053165131 | 3.6256505 | up | miR-650 | miR-605-3p | miR-876-5p | miR-526b-5p | miR-569 |
| hsa_circ_0006682 | 2.5579E-06 | 0.002191928 | 3.4860902 | up | miR-485-5p | miR-6884-5p | miR-377-5p | miR-6848-5p | miR-6866-5p |
| hsa_circ_0068784 | 4.17569E-06 | 0.002492284 | 3.5480508 | down | miR-4673 | miR-3692-5p | miR-6754-5p | miR-23a-3p | miR-7113-5p |
| hsa_circ_0057090 | 4.9948E-07 | 0.00147459 | 3.4927401 | down | miR-1193 | miR-548k | miR-643 | miR-3064-5p | miR-4299 |
| hsa_circ_0056247 | 2.22076E-05 | 0.003841024 | 3.2888045 | down | miR-450a-2-3p | miR-23b-5p | miR-23a-5p | miR-511-5p | miR-7-5p |
| hsa_circ_0001204 | 1.64596E-05 | 0.003817991 | 3.2644161 | down | miR-612 | miR-657 | miR-362-3p | miR-377-3p | miR-136-5p |
| hsa_circ_0001747 | 0.000218714 | 0.007377021 | 3.149758 | down | miR-616-5p | miR-30d-3p | miR-320b | miR-320a | miR-302c-5p |
| hsa_circ_0017311 | 5.30031E-05 | 0.004765914 | 3.0933966 | down | miR-767-3p | miR-412-3p | miR-335-3p | miR-191-3p | miR-421 |
| hsa_circ_0047744 | 5.99584E-05 | 0.004765914 | 3.0829551 | down | miR-503-5p | miR-424-5p | miR-15a-5p | miR-16-5p | miR-497-5p |
| hsa_circ_0030569 | 0.001000539 | 0.014333503 | 3.0627677 | down | miR-30d-3p | miR-29a-5p | miR-584-3p | miR-30a-3p | miR-30e-3p |
| hsa_circ_0089866 | 4.7015E-05 | 0.004765914 | 3.0233465 | down | miR-1914-5p | miR-556-5p | miR-3692-5p | miR-4268 | miR-4640-5p |
Note: We selected 18 differentially expressed circRNAs with the highest fold-change (fold-change >3.0; P < 0.05) to predict their miRNAs response elements (MREs), including 9 up-regulated circRNAs and 9 down-regulated circRNAs. The circRNAs/miRNAs interaction was predicted with Arraystar’s home-made miRNA target prediction software based on TargetScan and miRanda.