Table 1.

Combined PTEN loss and SHQ1-FOXP1 loss is associated with recurrence in primary prostate, breast, and head and neck cancer by multivariate Cox regression in TCGA cohorts

Cancer cohort	P-value	Hazard ratio	95% CI for HR
			Lower	Upper
Prostate cancer (TCGA cohort)
Indicator (neither FOXP1 nor PTEN loss)	NS
FOXP1 loss only (expression z < −1 or hemizygous or homozygous loss)	NS	0.607	0.179	2.061
PTEN loss only (expression z < −2 or hemizygous or homozygous CN loss)	NS	0.779	0.289	2.103
Both FOXP1 and PTEN loss	0.029	2.805	1.112	7.075
Breast cancer (TCGA cohort)
Indicator (neither FOXP1-SHQ1 nor PTEN loss)	NS
FOXP1-SHQ1 loss only (expression z < −1 or hemizygous or homozygous loss)	NS	1.190	0.563	2.515
PTEN loss only (expression z < −2 or hemizygous or homozygous CN loss)	NS	1.562	0.858	2.843
Both FOXP1-SHQ1 loss and PTEN loss	0.042	2.059	1.028	4.123
Head and neck cancer (TCGA cohort)
Indicator (neither FOXP1-SHQ1 nor PTEN loss)	NS
FOXP1-SHQ1 loss only (expression z < −1 or hemizygous or homozygous loss)	NS	1.970	0.977	3.974
PTEN loss only (expression z < −2 or hemizygous or homozygous CN loss)	NS	1.359	0.297	6.220
Both FOXP1-SHQ1 loss and PTEN loss	0.048	2.144	1.006	4.570

HR hazard ratio, CI confidence interval