Table 1.
Gene rs id | HWE for controls χ2 (P value) | Genotype/Allele | Case (n = 87) | Control (n = 94) | Odds ratio (95% CI) | P value |
---|---|---|---|---|---|---|
CCL2 rs1024611 | 1.13 (P = 0.287) | AA | 47 | 57 | 0.762 (0.42–1.37) | 0.452 |
AG | 22 | 30 | 0.722 (0.37–1.38) | 0.411 | ||
GG | 18 | 7 | 3.24 (1.28–8.2) | 0.016* | ||
A | 116 | 144 | 0.611 (0.38–0.96) | 0.046 | ||
G | 58 | 44 | 1.636 (1.03–2.59) | 0.046* | ||
CCL2 rs2857656 | 2.34 (P = 0.126) | GG | 56 | 60 | 1.023 (0.55–1.88) | 1 |
GC | 21 | 27 | 0.789 (0.40–1.53) | 0.505 | ||
CC | 9 | 7 | 1.434(0.51–4.03) | 0.603 | ||
G | 133 | 147 | 0.951 (0.57–1.56) | 0.899 | ||
C | 39 | 41 | 1.051 (0.63–1.72) | 0.899 | ||
CCL5 rs2280788 | 0.07 (P = 0.791) | CC | 75 | 89 | 0.35 (0.118–1.041) | 0.072 |
GC | 11 | 5 | 2.57 (0.857–7.744) | 0.115 | ||
GG | 1 | 0 | — | |||
C | 161 | 183 | 0.33 (0.118–0.969) | 0.05 | ||
G | 13 | 5 | 2.95 (1.031–8.47) | 0.05* | ||
CCL5 rs2107538 | 3.10 (P = 0.078) | GG | 39 | 46 | 0.84 (0.472–1.521) | 0.655 |
AG | 36 | 34 | 1.24 (0.684–2.268) | 0.541 | ||
AA | 11 | 14 | 0.82 (0.353–1.934) | 0.673 | ||
G | 114 | 126 | 0.96 (0.623–1.499) | 0.911 | ||
A | 58 | 62 | 1.03 (0.666–1.603) | 0.911 | ||
CCR2 rs1799864 | 2.34 (P = 0.125) | GG | 48 | 74 | 0.33 (0.173–0.637) | 0.0008* |
AG | 27 | 17 | 2.03 (1.017–4.081 | 0.05 | ||
AA | 9 | 3 | 3.5 (0.915–13.382) | 0.072 | ||
G | 123 | 165 | 0.40 (0.231–0.702) | 0.001* | ||
A | 45 | 23 | 2.62 (1.508–4.567) | 0.0006* | ||
CCR5 rs1799987 | 3.60 (P = 0.057) | GG | 31 | 35 | 0.93 (0.509–1.710) | 0.877 |
AG | 34 | 35 | 1.08 (0.593–1.971) | 0.878 | ||
AA | 22 | 20 | 1.25 (0.627–2.499) | 0.598 | ||
G | 96 | 105 | 0.97 (0.642–1.473) | 0.916 | ||
A | 78 | 83 | 1.02 (0.678–1.556) | 0.916 |
P values were calculated by chi square test and * denotes statistical significance at P < 0.05. Abbreviations: rs ID, reference SNP cluster ID; HWE, Hardy Weinberg Equilibrium; CI, confidence interval; P value, level of significance.