. 2017 Oct 20;7:13720. doi: 10.1038/s41598-017-13151-3

Table 3.

Results of univariate and multivariate Cox proportional-hazards regression for the analysis of the effects of baseline variables on an adverse endpoint.

Variable	Day 3				Day 7
	Univariate		Multivariate		Univariate		Multivariate
	HR (95%)	P	HR (95%)	P	HR (95%)	P	HR (95%)	P
Advanced age^a	3.973 (2.514–6.279)	0.000	3.251 (1.986–5.332)	0.000	4.001 (2.199–7.279)	0.000	3.511 (1.845–6.684)	0.000
High BI^b	3.258 (2.138–4.966)	0.000	2.070 (1.215–3.529)	0.007	4.343 (2.544–7.417)	0.000	2.475 (1.340–4.571)	0.004
Inhalation injury	3.533 (2.303–5.419)	0.000	1.999 (1.218–3.280)	0.006	3.757 (2.177–6.484)	0.000		NS
Mechanical ventilation	4.468 (2.921–6.835)	0.000	1.966 (1.108–3.488)	0.021	6.610 (3.753–11.645)	0.000	3.401 (1.761–6.570)	0.000
Operation during the first week^c	3.029(1.947–4.711)	0.000	3.128 (1.963–4.985)	0.000	2.116 (1.241–3.609)	0.006	3.002 (1.678–5.371)	0.000
Neutrophils	1.038 (1.006–1.071)	0.021	1.043 (1.013–1.075)	0.005		NS
RBC	0.741 (0.579–0.949)	0.017		NS	0.427 (0.282–0.646)	0.000	0.576 (0.354–0.938)	0.026
Hemoglobin	0.992 (0.985–1.000)	0.043		NS	0.977 (0.965–0.990)	0.000		NS
MCV		NS			1.105 (1.036–1.179)	0.002		NS
RDW (≥cutoff value)	2.398 (1.569–3.663)	0.000		NS	3.879 (1.896–7.973)	0.000		NS
PLT (≤cutoff value)	4.025 (2.645–6.124)	0.000		NS	4.591 (2.644–7.971)	0.000		NS
RPR (≥cutoff value)	4.563 (3.000–6.940)	0.000	2.385(1.433–3.968)	0.001	5.094 (2.962–8.759)	0.000	2.370 (1.320–4.254)	0.004

Note: Statistic significant factors in Table 1 were analyzed in univariate and multivariate regression analysis, respectively. Advanced age was defined as age ≥65 years. High BI was defined as burn index ≥50. The cutoff values for RDW, PLT, and RPR were shown in Table 2. NS: Non-significant.