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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Nature. 2017 May 24;546(7656):107–112. doi: 10.1038/nature22342

Figure 1. Fsh Antibody Reduces Obesity in Mice on a High-Fat Diet.

Figure 1

Fsh antibody (Ab) or goat IgG (200 µg/day/mouse, i.p.) injected for 8 weeks into 3-month-old female (F) and male (M) C57BL/6J mice pair-fed on high-fat diet. Shown are food intake and body weight (a); fat mass, fat mass/total mass (FM/TM) and lean mass/TM (LM/TM) by quantitative NMR (n=4 or 5 mice/group) (b); and total (TFV), subcutaneous (SFV) and visceral (VFV) fat volume by micro-CT (representative coronal and transverse sections from the same experiment; visceral, red; subcutaneous, yellow) (n=5 mice/group) (c). Two-tailed Student’s T-test; *P≤0.05, **P≤0.01; mean ± SEM.