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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Nature. 2017 May 24;546(7656):107–112. doi: 10.1038/nature22342

Figure 5. Fsh Ab Triggers Ucp1 Activation and Enhances Mitochondrial Biogenesis.

Figure 5

Three-month-old male ThermoMice pair-fed on high-fat diet and treated with Fsh antibody (Ab) or goat IgG (200 µg/mouse) for 8 weeks at room temperature (n as shown) (a) or 2.5 weeks at thermoneutral (30°C) conditions (n=3 or 4 mice/group) (b). ROI, region of interest. Ctrl, non-transgenic mice injected with D-Luciferin. Two-tailed Student’s T-test; *P≤0.05, ^P=0.060, ^^P=0.051; mean ± SEM. Construct used to generate the PhAMexcised mouse (mito: Cox8 mitochondria-localizing signal)30. Fluorescence captured in subcutaneous WAT (sWAT), visceral WAT (vWAT) and BAT after 2 weeks of Ab or IgG injection (c). Representative images from experiment using 3 mice/group.