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. 2017 Sep 12;24:56–63. doi: 10.1016/j.ebiom.2017.09.007

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© 2017 Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Plasma Hsp90α is a much better biomarker than AFP for the diagnosis of liver cancer. (A) shows ROC curve of plasma Hsp90α for HCC patients versus non-liver cancer group. (B) shows ROC curve of plasma Hsp90α for early-HCC patients versus non-liver cancer group. (C) shows ROC curve of plasma Hsp90α for AFP-negative HCC patients versus non-liver cancer group. (D) shows ROC curve of plasma Hsp90α for AFP-limited liver cancer patients versus non-liver cancer group. HCC indicates hepatocellular carcinoma. Non-LC indicates non-liver cancer control. Early-LC indicates patients with early-stage liver cancer. AFP-negative HCC indicates the HCC patients with serum AFP concentrations lower than 20 ng/mL. AFP-limited LC represents other types of liver cancer with exception of HCC, and in which AFP was not used to detect these patients. Early-HCC represents patients with early-stage hepatocellular carcinoma.