Table 1.
Results for measurement of plasma Hsp90α, AFP, or both in the diagnosis of hepatocellular carcinoma (HCC), or early-stage HCC.
| AUC (95%CI) | Cutoff (ng/mL) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Positive LR | Negative LR | |
|---|---|---|---|---|---|---|---|---|
| HCC vs Non-LC | ||||||||
| Hsp90α | 0.965(0.953–0.976) | 62.44 | 93.32 | 90.27 | 87.32 | 95.04 | 9.64 | 0.07 |
| AFP20a | 0.887(0.866–0.907) | 6.98 | 75.05 | 92.34 | 91.17 | 77.95 | 9.86 | 0.27 |
| Hsp90α + AFP | 0.977(0.968–0.985) | − | 93.70 | 94.40 | 91.91 | 95.63 | 14.69 | 0.07 |
| HCC vs At-risk | ||||||||
| Hsp90α | 0.938(0.910–0.967) | 73.23 | 89.00 | 90.20 | 96.53 | 72.64 | 8.96 | 0.12 |
| AFP20a | 0.851(0.820–0.883) | 6.171 | 76.82 | 83.01 | 93.54 | 52.23 | 4.44 | 0.28 |
| Hsp90α + AFP | 0.952(0.930–0.975) | − | 94.10 | 88.90 | 96.57 | 82.25 | 8.64 | 0.07 |
| Early-stage HCC vs Non-LC | ||||||||
| Hsp90α | 0.962(0.949–0.974) | 62.44 | 92.41 | 90.27 | 83.52 | 95.72 | 9.54 | 0.08 |
| AFP20a | 0.875(0.851–0.898) | 6.98 | 72.66 | 92.34 | 88.58 | 80.61 | 9.54 | 0.30 |
| Hsp90α + AFP | 0.974(0.964–0.983) | − | 92.70 | 94.4 | 91.13 | 94.06 | 16.68 | 0.08 |
| Early-stage HCC vs At-risk | ||||||||
| Hsp90α | 0.935(0.905–0.964) | 73.23 | 87.34 | 90.20 | 95.29 | 75.12 | 8.76 | 0.14 |
| AFP20a | 0.833(0.798–0.868) | 6.17 | 74.43 | 83.01 | 91.59 | 56.09 | 4.30 | 0.31 |
| Hsp90α + AFP | 0.949(0.925–0.972) | − | 92.70 | 88.90 | 95.56 | 82.74 | 8.50 | 0.08 |
HCC indicates hepatocellular carcinoma. Non-LC indicates non-liver cancer control. At-risk indicates non-cancerous liver diseases, including hepatitis, liver cirrhosis, focal nodular hyperplasia. Early-LC indicates patients with early-stage liver cancer. Hsp90α + AFP indicates the combined diagnosis with these two proteins. AUC represents area under curve. CI indicates confidence interval. Early-stage HCC represents patients with early-stage hepatocellular carcinoma. Hsp90α indicates heat shock protein 90alpha. AFP means α-fetoprotein. AUC represents area under curve. HC for healthy controls. PPV indicates positive predictive value. NPV means negative predictive value. LR represents likelihood ratio.
The commonly used cutoff value for AFP in HCC diagnosis.