Fig. 6.

BACE1 peptide inhibitors inhibits peripheral but not central Aβ production after systemic dosing. (a) Dose-dependent inhibition in plasma for the two lipid conjugated compounds BACE1_palm (green circle) and BACE1_chol (orange square) but not for the non-lipidated BACE1 peptide inhibitor (blue triangle). Black dotted line indicates plasma Aβ (pM) of vehicle control (black tringle). (b) None of the peptide inhibitors blocked Aβ production in the CNS compartment. Colour-coding as in (a). Red dashed line represents 50% Aβ inhibition. Values plotted are means ± SEM (n = 3). *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001 (t-test, compared to vehicle–dosed animals).