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. 2017 Sep 7;24:76–92. doi: 10.1016/j.ebiom.2017.09.004

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 8 — Lipidation of the BACE1 inhibitor peptide impacts transport of the BS construct over the BBB (a and b) Localization of injected BS-BACE1, BS-BACE1_palm, and BS-BACE1_chol 24 and 48 h after single i.v. dose (each 10 mg/kg) relative to endothelial CD31 signal (grey). (a) BS-BACE1 and BACE-1_palm were localized in mouse brain blood vessels 24 and 48 h post systemic application. Vascular localization of BS-BACE1_chol was observed at 24 h but not after 48 h. (b) High-resolution images of the 48 h time point highlight differences in vascular (CD31) localization of BS-BACE1_chol compared to BS-BACE1. (c) TfR expression in mouse brain 5–48 h after single intravenous dose (10 mg/kg) of BS-BACE1, BS-BACE1_palm and BS-BACE1_chol. TfR protein levels was stable (about 100 kDa) compared the control housekeeping gene β-actin (about 38 kDa).