Table 1.

Resume of the biological approaches used for treatment of GBS in animal studies.

Drugs	Biological Approach	Type of Study	Subjects	Efficient /Non-efficient	Year and Author
Cobra venom factor (CVF)	Complement modulation	Original article	Lewis rats	Efficient	1987/Feasby [31]
Soluble complement receptor type I (sCR I)	Complement modulation	Original article	Lewis rats	Efficient	1995/Jung [32]
IFN type I (α & β)	Cytokine modulation	Original article	Lewis rats	Efficient	1996/Vriesendorp [76]
Anti-CD2 mAb (OX34)	T cell modulation	Original article	Lewis rats	Efficient	1996/Jung [55]
Linomide	Cytokine modulation	Original article	Lewis rats	Efficient	1997/Bai [89]
Anti L-selectin mAb (HRL3)	T cells and monocytes trans-endothelial migration modulation	Original article	Lewis rats	Efficient	1997/Archelos [56]
IFNβ	Cytokine modulation	Original article	Lewis rats	Efficient	1999/Zou [78]
Rolipram	Cytokine modulation	Original article	Lewis rats	Efficient	2000/Abbas [93]
Anti-IL-18 mAb	Cytokine modulation	Original article	mice	Efficient	2002/Yu [94]
TNF receptor type I (TNFR I)	Cytokine modulation	Original article	mice	Efficient	2003/Bao [82]
APT070 (Mirococept)	Complement modulation	Original article	mice	Efficient	2005/Halstead [33]
Neutralizing anti-MIF mAb	Cytokine modulation	Original article	mice	Efficient	2005/Nikoletti [96]
rEV576	Complement modulation	Original article	mice	Efficient	2008/Halstead [45]
Eculizumab	Complement modulation	Original article	mice	Efficient	2008/Halstead [41]
Nafamostat mesilate (NM)	Complement modulation	Original article	rabbit	Efficient	2008/Phongsisay [46]
Anti-GD3 anti-idiotype mAb (BEC2)	Autoantibody modulation	Original article	Lewis rats	Efficient	2010/Usuki [49]
Erythropoietin	Cytokine modulation	Original article	Lewis rats	Efficient	2011/Mausberg [100]
Erythropoietin	Cytokine modulation	Original article	Lewis rats	Efficient	2011/Zhang [101]
Anti-C1q monoclonal antibody (M1)	Complement modulation	Original article	mice	Efficient	2016/McGonigal [50]