Table 1.
Rare IRX3 variants were enriched in young obese subjects in comparison to lean controls.
| Ntotal (male) |
Age (yrs) |
BMI (kg/m2) |
RareIRX3variant |
|||||
|---|---|---|---|---|---|---|---|---|
| Median (inter-quartile range) | Range | Median(inter-quartile range) | Range | N(%) | OR (95% CI) | Pvalue | ||
| Stage 1 | ||||||||
| Cases | 227 (98) | 21 (18, 25) | 13.0–30.0 | 38.4 (36.8, 41.2) | 35.0–61.7 | 5 (2.20) | – | 0.061 |
| Controls | 219 (92) | 38.4 (36.8, 41.2) | 13.0–30.0 | 20.4 (19.5, 21.6) | 17–23.0 | 0 (0) | ||
| Stage 2 | ||||||||
| Cases | 634 (262) | 22 (18, 26) | 12.0–30.0 | 34.6 (32.9, 37.3) | 30.0–63.3 | 14 (2.21) | 1.73 (0.74, 4.02) | 0.20 |
| Controls | 697 (244) | 25 (22, 28) | 14.0–58.0 | 19.5 (18.3, 21.0) | 17.5–23.0 | 9 (1.29) | ||
| Combined | ||||||||
| Cases | 861 (360) | 22 (18, 25) | 12.0–30.0 | 35.9 (33.6, 38.9) | 30.0–63.3 | 19 (2.21) | 2.27 (1.02, 5.05) | 0.038 |
| Controls | 916 (336) | 24 (21, 27) | 13.0–58.0 | 19.8 (18.6, 1.1) | 17.5–23.0 | 9 (0.98) | ||
N, sample size; Yrs, years; BMI, body mass index; OR, odds ratio; CI, confidence interval.
P values were calculated using χ2 tests.