Table 3.
Univariate and Multivariate regression analysis for mortality risk in the single site (validation) cohort. OR: Odds Ratio; CI: confidence interval.
| Univariate |
Multivariate (N = 1878) |
|||||
|---|---|---|---|---|---|---|
| OR | CI 95% | p | OR | CI 95% | p | |
| Smoking | < 0.001 | 0.059 | ||||
| No smoker | 1 | – | – | 1 | – | – |
| Smoker | 0.39 | 0.25–0.61 | < 0.001 | 0.47 | 0.25–0.88 | 0.019 |
| Ex-smoker | 0.69 | 0.51–0.94 | 0.017 | 0.80 | 0.53–1.21 | 0.29 |
| Cardiac disease | 1.45 | 1.02–2.04 | 0.038 | – | – | – |
| Chronic renal failure | 1.83 | 1.21–2.78 | 0.004 | – | – | – |
| Neurological disease | 3.64 | 2.75–4.82 | < 0.001 | 2.41 | 1.60–3.63 | < 0.001 |
| CURB-65 ≥ 3 | 3.42 | 2.51–4.66 | < 0.001 | 2.85 | 1.92–4.23 | < 0.001 |
| ARDS (complication) | 3.40 | 2.15–5.37 | < 0.001 | 3.29 | 1.78–6.09 | < 0.001 |
| Respiratory virus | 0.44 | 0.21–0.89 | 0.024 | – | – | – |
| Initial ICU admission | 1.54 | 1.14–2.09 | 0.005 | 1.91 | 1.22–2.99 | 0.005 |
| Appropriate antibiotic treatment | 0.34 | 0.20–0.57 | < 0.001 | 0.41 | 0.21–0.80 | 0.009 |
| Lymphocytes (cell/mm3) (Ln) | 0.92 | 0.86–0.98 | 0.008 | 0.89 | 0.81–0.98 | 0.023 |