Fig. 1.

Ad-Lkb1 mice develop hindlimb paralysis starting at 8-month-old. (a) Targeting strategy for adipocyte-specific deletion of Lkb1. Black box represents deleted exons and triangles represent LoxP sites. (b and c) Representative images of WT and paralyzed KO mice (8-month-old). KO mice clench the hind limbs to the body when suspended by the tail (b), drag hind limbs and are unable to keep the body balance (c). (d) Foot-prints of a paralyzed KO and a normal WT mouse (9-month-old), fore-paws were immersed in red ink and hind limbs were immersed in blue ink. (e and f) Occurrence rate of paralysis in WT and KO male (n = 11 pairs) and female (n = 14 pairs) mice. The number of samples are biological replicates.