Table II.
Mitochondrial DNA D-loop somatic mutations in patients with brain tumors.
| Patient code | Tumor type | Nucleotide position | Somatic mutation | Homoplasmy/heteroplasmy | Novel/reported | (Refs.) |
|---|---|---|---|---|---|---|
| ID003 | GBM IV | 16265 | A-G | Homoplasmy | Bladder | (33) |
| Leukemia | (34) | |||||
| Prostate cancer | (35) | |||||
| ID004 | GBM IV | 303 | CC insertion | Homoplasmy | Brain tumor | (32) |
| Gastric cancer | (36) | |||||
| Breast | (37) | |||||
| Oral | (38 | |||||
| 414 | T-G | Homoplasmy | Colorectal | (39) | ||
| 476a | C-A/C | Heteroplasmy | Novela | Present study | ||
| ID005 | GBM IV | 195 | T-C | Homoplasmy | Brain tumor | (28,29) |
| Ovarian | (40) | |||||
| Breast | (41) | |||||
| Leukemia | (42) | |||||
| ID006 | AA III | 16356 | T-C | Homoplasmy | Brain tumor | (28) |
| Breast | (41) | |||||
| ID007 | Meningioma I | 249 | A deletion | Homoplasmy | Nasopharyngeal | (43) |
| carcinoma | (44) | |||||
| Breast | (35a) | |||||
| Prostate cancer | ||||||
| 73 | A-G | Homoplasmy | Prostate cancer | (45) | ||
| Brain tumor | (29) | |||||
| Breast | (41) | |||||
| Leukemia | (42) | |||||
| ID008 | GBM IV | 249 | A deletion | Homoplasmy | Nasopharyngeal | (43) |
| carcinoma | (44) | |||||
| Breast | (35a) | |||||
| Prostate | ||||||
| 311 | C insertion | Homoplasmy | Brain tumor | (32) | ||
| Breast | (37) | |||||
| Leukemia | (42) | |||||
| 73 | A-G | Homoplasmy | Prostate cancer | (45) | ||
| Brain tumor | (29) | |||||
| Breast | (41) | |||||
| Leukemia | (42) | |||||
| 16356 | T-C | Homoplasmy | Brain tumor | (28) | ||
| Breast | (41) | |||||
| ID011 | PA | 303 | C insertion | Homoplasmy | Brain tumor | (32) |
| Gastric cancer | (36) | |||||
| Breast | (37) | |||||
| Oral | (38) | |||||
| 311 | C insertion | Homoplasmy | Brain tumor | (32) | ||
| Breast | (37) | |||||
| Leukemia | (42) | |||||
| ID013 | PA | 16325 | T-C | Homoplasmy | Brain tumor | (32) |
| Leukemia | (34) | |||||
| Breast | (37) | |||||
| ID014 | AA III | 249 | A deletion | Homoplasmy | Nasopharyngeal | (43) |
| carcinoma | (44) | |||||
| Breast | (35a) | |||||
| Prostate | ||||||
| 311 | C insertion | Homoplasmy | Brain tumor | (32) | ||
| Breast | (37) | |||||
| Leukemia | (42) | |||||
| ID017 | GBM IV | 311 | C insertion | Homoplasmy | Brain tumor | (32) |
| Breast | (37) | |||||
| Leukemia | (42) | |||||
| 511 | C-T | Homoplasmy | Cervical cancer | (46) | ||
| ID019 | Meningioma I | 146 | T-C | Homoplasmy | Brain tumor | (29) |
| Breast | (37) | |||||
| Leukemia | (42) | |||||
| Oral | (38) | |||||
| 204 | T-C | Homoplasmy | Brain tumor | (28) | ||
| Ovarian | (47) | |||||
| Leukemia | (34,42) | |||||
| 16519 | T-C | Homoplasmy | Brain tumor | (28) | ||
| Leukemia | (34) | |||||
| Gastric cancer | (36) | |||||
| Breast | (41) | |||||
| ID020 | GBM IV | 195 | T-C | Homoplasmy | Brain tumor | (28,29) |
| Ovarian | (40) | |||||
| Breast | (41) | |||||
| Leukemia | (42) | |||||
| 303 | CC insertion | Homoplasmy | Brain tumor | (32) | ||
| Gastric cancer | (36) | |||||
| Breast | (37) | |||||
| Oral | (38) | |||||
| 411 | C-G/C | Heteroplasmy | Leukemia | (34) | ||
| 16381 | T-C | Homoplasmy | Reported in MITOMAP | MITOMAP | ||
| ID021 | Meningioma I | 176a | A deletion | Homoplasmy | Novela | Present study |
| 16265 | A-G | Homoplasmy | Bladder | (33) | ||
| Leukemia | (34) | |||||
| Prostate cancer | (35) | |||||
| ID022 | Meningioma I | 411 | C-G | Homoplasmy | Leukemia | (34) |
| 432 | A-C | Homoplasmy | Reported in MITOMAP | MITOMAP | ||
| ID024 | GBM IV | 186 | C-G | Homoplasmy | Oral cancer | (48) |
| ID026 | GBM IV | 71 | G deletion | Homoplasmy | Oral cancer | (49) |
| 311 | C insertion | Homoplasmy | Brain tumor | (32) | ||
| Breast | (37) | |||||
| Leukemia | (42) | |||||
| ID027 | GBM IV | 61 | C-A | Homoplasmy | Reported in MITOMAP | MITOMAP |
| 16381 | T-C | Homoplasmy | Reported in MITOMAP | MITOMAP | ||
| 16405a | A deletion | Homoplasmy | Novela | Present study | ||
| ID030 | GBM IV | 311 | C insertion | Homoplasmy | Brain tumor | (32) |
| Breast | (37) | |||||
| Leukemia | (42) | |||||
| 523–524 | AC deletion | Homoplasmy | Reported in MITOMAP | MITOMAP | ||
| ID036 | Meningioma I | 503 | A-G | Homoplasmy | Reported in MITOMAP | MITOMAP |
| 566a | C-A | Homoplasmy | Novela | Present study | ||
| ID038 | Meningioma I | 146 | T-C | Homoplasmy | Brain tumor | (29) |
| Breast | (37) | |||||
| Leukemia | (42) | |||||
| Oral | (38) | |||||
| 152 | T-C/T | Heteroplasmy | Brain tumor | (29) | ||
| Breast | (20,41) | |||||
| Laryngeal carcinoma | (50) | |||||
| ID039 | Meningioma I | 472 | A-G | Homoplasmy | Reported in MITOMAP | MITOMAP |
| ID042 | GBM IV | 16519 | T-C | Homoplasmy | Brain tumor | (28) |
| Leukemia | (34) | |||||
| Gastric cancer | (36) | |||||
| Breast | (41) | |||||
| ID044 | GBM IV | 146 | T-C | Homoplasmy | Brain tumor | (29) |
| Breast | (37) | |||||
| Leukemia | (42) | |||||
| Oral | (38) | |||||
| 204 | T-C | Homoplasmy | Brain tumor | (28) | ||
| Ovarian | (47) | |||||
| Leukemia | (34,42) | |||||
| ID045 | Meningioma I | 176a | A deletion | Homoplasmy | Novela | Present study |
| ID047 | Ependymoma | 16519 | T-C | Homoplasmy | Brain tumor | (28) |
| Leukemia | (34) | |||||
| Gastric cancer | (36) | |||||
| Breast | (41) |
a
Novel mutations; areported as a polymorphism; PA, pilocytic astrocytoma; AA III, anaplastic astrocytoma III; GBM, glioblastomas multiform.