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. 2017 Aug 25;14(5):5434–5442. doi: 10.3892/ol.2017.6829

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Copyright: © Brockton et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Frequency distributions of AQUA^® scores in OSCC patients and Kaplan-Meier survival curves according to the optimized AQUA^® score cut-off points derived using X-Tile^® software. (A) Frequency distribution histogram for Ki-67 AQUA^® scores. (B) Frequency distribution histogram for sCAIX AQUA^® scores. (C) Frequency distribution histogram for tCAIX AQUA^® scores. (D) Kaplan-Meier survival curve according to optimized threshold value for Ki-67 AQUA^® scores. (E) Kaplan-Meier survival curve according to optimized threshold value for sCAIX AQUA^® scores. (F) Kaplan-Meier survival curve according to optimized threshold value for tCAIX AQUA^® scores. OSCC, oral squamous cell carcinoma; AQUA, Automated Quantitative Analysis™; CAIX, carbonic anhydrase IX; t, tumoral, s, stromal.